The evolving genomic classification of lung cancer
نویسندگان
چکیده
منابع مشابه
The evolving genomic classification of lung cancer
EGFR gene mutations and ALK gene fusions are well-characterized molecular targets in NSCLC. Activating alterations in a variety of potential oncogenic driver genes have also been identified in NSCLC, including ROS1, RET, MET, HER2, and BRAF. Together with EGFR and ALK, these mutations account for ∼20% of NSCLCs. The identification of these oncogenic drivers has led to the design of rationally t...
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Cancer of the lung is the leading cause of cancer death in both women and men in the United States. In the year 2012, the estimate is for 226,160 new cases of lung cancer in the US, and 164,770 deaths; the five-year survival rate for lung cancer is 16%. This sobering outlook is due primarily to the fact that most patients have advanced disease at the time of presentation. Nonsmall cell lung can...
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Better approaches are needed to evaluate a single patient's drug response at the genomic level. Targeted therapy for signaling pathways in cancer has met limited success in part due to the exceedingly interwoven nature of the pathways. In particular, the highly complex RAS network has been challenging to target. Effectively targeting the pathway requires development of techniques that measure g...
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In 1924, when lung cancer was an uncommon disease , Marchesani proposed a classification of lung cancer into four histological groups. This was later expanded in the World Health Organisation's his-tological classification of lung tumours of 1967.' Further modification was found necessary and a second edition was produced by the WHO in 1981.2 This includes, under the heading "Malignant epitheli...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2013
ISSN: 0022-3417,1096-9896
DOI: 10.1002/path.4275